{"id":769,"date":"2026-02-12T07:20:41","date_gmt":"2026-02-12T07:20:41","guid":{"rendered":"https:\/\/icgeb-alsftd-rijeka-croatia2026.com\/?page_id=769"},"modified":"2026-04-08T14:19:51","modified_gmt":"2026-04-08T14:19:51","slug":"programme","status":"publish","type":"page","link":"https:\/\/icgeb-alsftd-rijeka-croatia2026.com\/index.php\/programme\/","title":{"rendered":"Programme"},"content":{"rendered":"\t\t
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Preliminary program<\/h2>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t\r\n\t\t\t\t\t\t\t\t<\/i>\r\n\t\t\t\t\t\t\t\t<\/i>\r\n\t\t\t\t\t\t\t<\/span>\r\n\t\t\t\t\t\t\t\r\n\t\t\t\t\t\tTuesday, June 30\t\t\t\t\t<\/div>\r\n\r\n\t\t\t\t\t
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8.00 - 9.00<\/strong><\/span>\u00a0 \u00a0 \u00a0 \u00a0Registration<\/strong><\/p>

9.00 - 11.00\u00a0 \u00a0 \u00a0<\/strong><\/span>Session 1 <\/strong>(Chairs: A. Markovinovic & E. Buratti): ALS\/FTD: new mechanisms <\/strong><\/p>

Opening ceremony<\/strong> (Introductory speeches by the Rectorate and Organizers)<\/p>

Pietro Fratta <\/strong>(University College London, London, UK): TDP -43 dysfunction and T cells<\/p>

Emanuele Buratti <\/strong>(ICGEB, Trieste, Italy): <\/strong>TDP-43 and AI-based search for novel\u00a0biomarkers and small molecule interactors<\/span><\/p>

Chantelle Sephton <\/strong>(Laval University, Quebec, Canada): Metabolic homeostasis in ALS: linking energy metabolism to FUS proteostasis<\/p>

Andrea Markovinovic <\/strong>(Faculty of Medicine, Rijeka, Croatia): ER-mitochondria interactions in ALS\/FTD\u00a0<\/strong><\/p>

Morwena Latouche<\/strong>\u00a0(Sorbonne University, Brain and Spinal cord Institute,Paris, France):\u00a0<\/span>Neuro-immune forebrain assembloids from C9ORF72 and GRN mutant hIPSC<\/span><\/p>

Awarded talk: Carmelo Milioto<\/strong> (University of Milan, Italy): C9orf72 DPR knock-in mice shape motor neuron vulnerability and plasticity revealing a novel potential therapeutic axis in ALS\/FTD<\/p>

11.00 - 11.30<\/strong><\/span> \u00a0\u00a0\u00a0\u00a0Coffee break<\/strong><\/p>

11.30 - 13.30<\/strong><\/span>\u00a0 \u00a0 \u00a0Session 2 <\/strong>(Chairs: E. Buratti & J. Mitchell): ALS\/FTD: new mechanisms<\/strong><\/p>

Jean-Pierre Julien <\/strong>(Laval University, Quebec, Canada): The role of neurofilaments in TDP-43 pathology<\/p>

Jacqueline Mitchell<\/strong> (King's College London, UK): TDP-43 pathogenesis: unpicking\u00a0 differential vulnerability and environmental contributors<\/p>

David Brenner <\/strong>(University of Ulm, Germany): Personalized medicine for genetic ALS - from bedside to bench and back to bedside<\/p>

Marco Baralle <\/strong>(ICGEB, Trieste, Italy): Determinants of TDP-43 expression: Epigenetic and genetic regulation<\/p>

Manuela Basso <\/strong>(University of Trento, Italy): Neuroinflammation and neurodegeneration: different timelines of two occurring events in ALS?<\/p>

Awarded talk: Lea Knez <\/strong>(University College London, London, UK): Development\u00a0 of a safe and effective gene therapy to rescue TDP-43 loss-of-function<\/p>

Awarded talk: Ismail Gbadamosi <\/strong>(Nencki Institute of Experimental Biology, Warsaw, Poland): Cell-specific Neuroglia Metabolic Reprogramming Downstream TDP-43 Dysfunction<\/p>

13.30 \u2013 15.00<\/strong><\/span>\u00a0\u00a0\u00a0Lunch<\/strong><\/p>

15.00 \u2013 16.20<\/strong><\/span>\u00a0\u00a0\u00a0Session 2 continued <\/strong>(Chairs: B. Rogelj & P. Fratta): Proteinopathy in ALS\/FTD<\/strong><\/p>

Boris Rogelj <\/strong>(Department of Biotechnology, Jozef Stefan Institute): Interactomics in ALS and FTD<\/p>

Michael Strong<\/strong> (Schulich School of Medicine & Dentistry, Western University, London, Canada): TDP-43 interaction with SARS-CoV-2 nucleocapsid protein (N protein) \u2013 biomolecular condensate formation<\/p>

Angelo Poletti <\/strong>(University of Milan, Italy): <\/strong>Novel approaches to counteract DPRs neurotoxicity in C9ORF72-linked ALS and FTD<\/p>

Giulia De Sabbata<\/strong> (VectorY Therapeutics B.V., Amsterdam, Netherlands): AAV-mediated delivery of an intrabody targeting TDP-43 for Amyotrophic Lateral Sclerosis therapy<\/p>

Awarded talk: Jerneja Nimac<\/strong> (Department of Biotechnology, Jozef Stefan Institute): Stress-associated dynamic interactome of TDP-43<\/span><\/p>

18.30 - 20.00<\/strong><\/span>\u00a0\u00a0\u00a0\u00a0Swim & Walk for Brain Health @ Kostrena beach<\/strong><\/p>

20.00 - 22.30<\/strong><\/span>\u00a0\u00a0\u00a0\u00a0\u00a0Drinks and snacks in Kostrena Yacht Club Galeb<\/strong><\/p>\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\r\n\t\t\t\t\r\n\t\t\t\t

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9.00 - 11.00 <\/strong><\/span>\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0Session 3 <\/strong>(chairs: J-P. Julien & I. Munitic): Immunity in ALS\/FTD<\/strong><\/p>

Jasna Kriz <\/strong>(Laval University, CERVO Brain Research Centre): Development of distinct microglia proteome profiles in TDP-43 mediated pathologies<\/p>

Jemeen Sreedharan<\/strong> (King\u2019s College London, UK): TDP-43-linked inflammatory signals in mouse and stem cell-derived neurons<\/p>

Christian Lobsiger <\/strong>(Sorbonne University, Brain and Spinal cord Institute, Paris, France): How microglial TBK1 and motor neuron aging could contribute to ALS disease<\/p>

Ivana Munitic <\/strong>(Faculty of Biotechnology and Drug Development, University of Rijeka, Croatia): OPTN <\/em>Variants as Disease Modifiers: Lessons from Experimental Models and Computational Analyses<\/p>

Valeria Gerbino <\/strong>(IRCSS Fondazione Santa Lucia, European Center for Brain Research, Rome, Italy): TBK1 at the intersection of proteostasis and neuroinflammation in neurodegenerative disease progression<\/span><\/p>

11.00 - 11.30<\/strong><\/span>\u00a0\u00a0\u00a0\u00a0\u00a0Coffee break<\/strong><\/p>

11.30 - 13.30<\/strong><\/span>\u00a0\u00a0\u00a0\u00a0\u00a0Session 3 continued <\/strong>(chairs: J-P. Julien & I. Munitic): Immunity in ALS\/FTD & beyond<\/strong><\/p>

Ludo Van Den Bosch<\/strong> (University of Leuven, Belgium): Dynamic interplay between loss-of-support and gain-of-toxicity by ALS astrocytes on human motor units\u00a0\u00a0<\/p>

Ilija Brizic <\/strong>(Center for Proteomics, Faculty of Medicine, University of Rijeka, Croatia): Glial cell adaptation to latent cytomegalovirus infection in the CNS<\/p>

Jason Cannon <\/strong>(Purdue University, West Lafayette, USA): Ferroptosis cell death pathways as a critical pathogenic intersection across multiple neurodegenerative diseases<\/span><\/p>

Marina Babi\u0107<\/strong>\u00a0<\/strong>\u010ca\u010d<\/strong>\u00a0<\/strong>(Faculty of Medicine, Rijeka, Croatia): Regulation of Lymphocyte Responses During Neuroinflammation<\/p>

Ludmilla Morozova-Roche<\/strong> (Ume\u00e5 University, Sweden): Role of proinflammatory S100A9 protein in the amyloid-neuroinflammatory cascade in neurodegenerative diseases<\/p>

13.30 - 15.00 <\/strong><\/span>\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0Lunch<\/strong><\/p>

15.00 - 17.00<\/strong><\/span>\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0Session 4 <\/strong>(chairs: S.Kalra & F. De Marchi): Clinical studies, biomarkers & emerging therapies in ALS\/FTD<\/strong><\/p>

Angela Genge <\/strong>(McGill University, Quebec, Canada): Update on Targets in ALS Drug Development<\/p>

Sanjay Kalra <\/strong>(University of Alberta, Edmonton, Alberta, Canada): Cerebral Degeneration in ALS: Insights from Neuroimaging<\/p>

Hrvoje Bili\u0107 <\/strong>(Clinical Hospital Centre Zagreb, Croatia): Tofersen: real-world data in Croatian patients<\/p>

Bla\u017e Koritnik <\/strong>(Institute of Clinical Neurophysiology, University Medical Centre Ljubljana): Clinical perspectives on ALS genetics<\/p>

Fabiola De Marchi\u00a0<\/span>(University of Piemonte Orientale, Maggiore della Carit\u00e0 Hospital, Novara, Italy): Stem cell based clinical trials in ALS\/FTD and beyond<\/span><\/p>

Aleksandra Kacar\u00a0<\/strong>(University Clinical Center of Serbia, Belgrade, Serbia): Electrophysiological markers in ALS\u00a0\u00a0 \u00a0 \u00a0 \u00a0 \u00a0\u00a0<\/p>

Ante Toli\u0107 <\/b>(Clinical Hospital Centre, Rijeka, Croatia): Tofersen treatment in ALS SOD-1 positive patients in Clinical Hospital Centre Rijeka<\/span>\u00a0<\/span><\/p>

17.00 - 19.00<\/strong><\/span>\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0Poster session with coffee & cookies<\/strong><\/p>

19.30 - 23.00<\/strong><\/span>\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0Dinner for invited speakers & organizing committee\u00a0<\/strong>\"\ud83c\udf41\"\u00a0Canada day <\/strong>celebration with Canadian friends in Croatia! \"\ud83c\udf41\"<\/strong><\/p>\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\r\n\t\t\t\t\r\n\t\t\t\t

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9.00 - 11.00<\/strong><\/span>       Session 5 <\/strong>(chairs: J. Kriz & J. Cannon): Systems and multi-omics approaches ALS\/FTD and related brain disorders<\/strong><\/p>\n

Robert Russell<\/strong> (Heidelberg University, Germany): Predicting disease variant molecular mechanism: from first year biochemistry to sophisticated AI models<\/p>\n

Vladimira Vuleti\u0107 <\/strong>(Clinical Hospital Centre, Rijeka): Precise and personalized therapy in neurodegenerative diseases - examples from everyday practice<\/p>\n

Sandra Maria Martin Guerrero <\/strong>(Instituto de Parasitolog\u00eda y Biomedicina L\u00f3pez-Neyra, CSIC, Granada, Spain): Maternal Immune Activation as a driver of protein dysregulation in neural progenitors<\/p>\n

Lea El Hajjar<\/strong> (Sorbonne University, Brain and Spinal cord Institute, Paris, France): In vitro experimental validation pipeline for discovering small\u2011molecule inhibitors of TDP\u201143 aggregation<\/p>\n

Sara Cappelli<\/strong> (ICGEB, Triste, Italy): From Blood to Brain: Unveiling Platelet\u2013Neuron Crosstalk in ALS and FTD<\/p>\n

Dijana Ostoji\u0107 <\/strong>(University of Galway, Ireland): Investigating the metabolomic signatures of schizophrenia and frontotemporal dementia in UK Biobank<\/p>\n

Awarded talk: Benedetta Bartilomo<\/strong> (University of Piemonte Orientale, Novara, Italy): A Multi-Hit Genetic Model for Motor Neuron Vulnerability Machine Learning-Based Identification of Variant Convergence in ALS-Related Gene Networks<\/span><\/p>\n

Awarded talk:<\/span> <\/span>Giovanni Papagni<\/strong> (University of Piemonte Orientale, Novara, Italy): Application of High Throughput Approaches for the Functional Characterization of  VUS in ALS  and Neurodegenerative Diseases<\/span><\/p>\n

11.00 - 11.30<\/strong><\/span>    Coffee break<\/strong><\/p>\n

11.30 - 13.30<\/strong><\/span>    Session 6 <\/strong>(chairs: V. Vuleti\u0107 & E. Stefanova): <\/em><\/strong>Overlapping pathologies in neurodegenerative diseases<\/strong><\/p>\n

Dmitry Lim<\/strong> (University of Piemonte Orientale, Novara, Italy): A chicken and the egg: ER-mitochondrial interaction and protein homeostasis in Alzheimer\u2019s disease and beyond<\/span><\/p>\n

Dubravka Svob Strac <\/strong>(Ru\u0111er Bo\u0161kovi\u0107 Institute, Zagreb, Croatia): Dehydroepiandrosterone Sulphate Mitigates A\u03b2 Toxicity and Accumulation in Experimental Models of Alzheimer\u2019s Disease Selected speaker<\/span><\/p>\n

Elka Stefanova <\/strong>(Faculty of Medicine, University of Belgrade):<\/strong> The role of C9orf72 in neurodegenerative diseases<\/p>\n

Silva Katu\u0161i\u0107 He\u0107imovi\u0107 <\/strong>(Ru\u0111er Bo\u0161kovi\u0107 Institute, Zagreb, Croatia): Proteome and lipidome signatures of a juvenile neurodegenerative disorder Niemann-Pick type C<\/p>\n

Laura Tapella<\/strong> (University of Piemonte Orientale, Novara, Italy): Calcineurin in astrocytes and its role in proteostasis and neuroinflammation<\/p>\n

Victor <\/strong>Coelho <\/span>(Laval University, CERVO Brain Research Centre): Converging SRSF3 immune-mediated mechanisms in ALS\/FTD and AD models<\/span><\/p>\n

Award for best young researcher presentation & best NeuroArt Contest Artwork<\/strong><\/p>\n

Closing ceremony<\/strong><\/p>\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\r\n\t\t\t\t\r\n\t\t<\/div>\r\n\r\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Preliminary program Tuesday, June 30 8.00 – 9.00\u00a0 \u00a0 \u00a0 \u00a0Registration 9.00 – 11.00\u00a0 \u00a0 \u00a0Session 1 (Chairs: A. Markovinovic & E. Buratti): ALS\/FTD: new mechanisms Opening ceremony (Introductory speeches by the Rectorate and Organizers) Pietro Fratta (University College London, London, UK): TDP -43 dysfunction and T cells Emanuele Buratti (ICGEB, Trieste, Italy): TDP-43 and […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-769","page","type-page","status-publish","hentry","entry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/icgeb-alsftd-rijeka-croatia2026.com\/index.php\/wp-json\/wp\/v2\/pages\/769","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/icgeb-alsftd-rijeka-croatia2026.com\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/icgeb-alsftd-rijeka-croatia2026.com\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/icgeb-alsftd-rijeka-croatia2026.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/icgeb-alsftd-rijeka-croatia2026.com\/index.php\/wp-json\/wp\/v2\/comments?post=769"}],"version-history":[{"count":36,"href":"https:\/\/icgeb-alsftd-rijeka-croatia2026.com\/index.php\/wp-json\/wp\/v2\/pages\/769\/revisions"}],"predecessor-version":[{"id":994,"href":"https:\/\/icgeb-alsftd-rijeka-croatia2026.com\/index.php\/wp-json\/wp\/v2\/pages\/769\/revisions\/994"}],"wp:attachment":[{"href":"https:\/\/icgeb-alsftd-rijeka-croatia2026.com\/index.php\/wp-json\/wp\/v2\/media?parent=769"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}